A glioma is a type of spinal or brain tumor. These tumors begin in glial cells, which are cells in the central nervous system (CNS) that that support neurons or nerve cells. The term “glial” comes from the Greek word for “glue.” Glial cells are the most common types of cells in the CNS and can be broken down into a variety of subtypes. These include:
A glioma is a cancerous tumor that originates in one of those cell types. Gliomas are subdivided into:
The exact cause of a glioma is not known in most cases. There are, however, a number of factors that increase the risk of developing gliomas, such as:
Glioma symptoms depend on the type, size and location of the tumor. Some common symptoms can include:
Doctors will usually start with a medical history and physical exam to determine the presence of symptoms and if there is a family history of glioma. Next is usually a neurological exam, which can include tests for:
Some type of imaging test is usually necessary for a firmer diagnosis. These can include magnetic resonance imaging (MRI) or computed tomography (CT) scans. However, a biopsy—taking a small piece of tumor and evaluating it under a microscope—is the only way to truly diagnose a glioma. A biopsy can be done as part of surgery to remove a brain tumor, or it can be done with a stereotactic needle that is inserted into the brain and often guided by an MRI or CT scan.
Glioma treatment depends on its grade (severity). While there are four grades, gliomas are often referred to as either low grade (grades I or II) or high grade (grades III or IV). In most cases, surgery to remove all or as much of the tumor as possible is the first step. In many cases, however, the tumor is either too large to fully remove, is located in a particularly sensitive area in the brain or is difficult to access. In such cases, surgeons will remove as much of the tumor as is safely possible.
After surgery, radiation therapy is often the next step. Radiation uses high-energy beams such as X-rays or protons focused on the tumor to destroy cancerous cells. Chemotherapy—medications used to kill cancer cells—is often given in conjunction with radiation.
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